4D-MSPECT is a comprehensive cardiac ECT quantification and display program for gated and ungated ECT perfusion and studies developed at the University of Michigan Medical Center in Ann Arbor, Michigan. 4D-MSPECT is designed to process cardiac ECT studies and then display the images and quantitative results in many user selectable formats.

4D-MSPECT can process, analyze and display reconstructed cardiac tomographic studies of all types. The application allows users to select from among a number of different quantification and display routines through a standardized user interface. The application allows users to select from among a number of different single or multi-dimensional display(s).

A Normals Database Generator is an integrated feature of 4D-MSPECT that provides the individual user with a set of tools for generating site, patient population or protocol specific normal data files. Site specific Normals Databases are integrated seamlessly into the application for research or daily clinical use. This is a user friendly sophisticated module that provides individual subject and population statistics and the ability to review and edit the included studies (n=20 to 256) at the users convenience. Included in 4D-MSPECT is a validated normals database for the dual isotope rest Tl-201 stress Tc-99m-Sestamibi protocol, two day and one day Tc-99m-Sestamibi protocols.

Quality assurance is an important part of the operations of any successful Nuclear Imaging laboratory. 4D-MSPECT provides several options for verifying the quality of the input data and the processing of that data. Raw data cines, surface, valve plane and polarmap QA of all displayed studies are all provided and available both during processing and subsequently during image interpretation.

• 2D image display of left ventricular (LV) myocardial surfaces with calibrated LV volume curve
  
• 2D comparative slice image displays of End-Diastolic and End-Systolic images
  
• 2D comparative slice image displays of aligned and normalized short-axis and/or vertical and horizontal long-axis images simultaneously for up to three image files from any one patient
  
• 2D comparative slice image displays of aligned, normalized and aligned, with 3D surface displays
  
• 3D surface display of left ventricle with either perfusion, wall thickening or wall motion data overlaid on cardiac surfaces
  
• 3D surface display of left ventricle with endocardial and epicardial surfaces displayed in either transparent, wireframe, or opaque geometries
  
• 3D multi-view comparison displays of stress and rest image sets (up to 3 data sets can be simultaneously displayed
  
• Polarmaps of quantified perfusion (Ungated, ED and ES), wall motion and wall thickening
  

• Raw Polarmap Data
  
• Normalized Polarmap Data
  
• Defect Severity Maps
  
• Blackout Maps
  
• Reversibility Maps
  
• Normal Database Mean Maps
  
• Normal Database Standard Deviation Maps
  
• Segmentation overlays:
  
• Three Coronary Vascular Territories
  
• 5, 9, 13, 17, 19, and 20 Segment Overlays
  
• Bar plot displays of vascular statistics
  
• User definable thresholds for defect estimation and analysis
  
• Circumferential Profile Analysis
  
• Comparison of study profiles to normal database values.

• Cine displays of normalized raw projection images with reference cursor lines
• Snapshot Reviewer
• Ability to save and view snapshots for screen displays
• Ability to make snapshots of display screens in TIFF format for exportation.